Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products, implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. (...) Nanotherapeutics andin vivonanodiagnostics incorporate materials that are engineered at the nanoscale to express novel properties that are medicinally useful. These nanomedicine applications can also contain nanomaterials that are biologically active, producing interactions that depend on biological triggers. Examples include nanoscale formulations of insoluble drugs to improve bioavailability and pharmacokinetics, drugs encapsulated in hollow nanoparticles with the ability to target and cross cellular and tissue membranes and to release their payload at a specific time or location, imaging agents that demonstrate novel optical properties to aid in locating micrometastases, and antimicrobial and drug-eluting components or coatings of implantable medical devices such as stents. (shrink)

FIRST MERTTENS LECTURE ON WAR AND PEACE JUSTICE AMONG NATIONS BY HORACE G. ALEXANDER, M. A. LECTURER ON INTERNATIONAL LAW AND POLITICS AT WOODBROOKE, SBLLY OAK, ...

Ethical mysticism, by S. Coit.--The ethical import of history, by D. S. Muzzey.--The tragic and heroic in life, by W. M. Salter.--Distinctive features of the ethical movement, by A. W. Martin.--Ethical experience as the basis of religious education, by H. Neumann.--"All men are created equal," by G. E. O'Dell.--How far is art an aid to religion? by P. Chubb.--Evolution and the uniqueness of man, by H. J. Bridges.--The spiritual outlook on life, by H. J. Golding.--The ethics of Abu'l Ala al (...) Ma'arri, by N. Schmidt.--Life's unused moral force, by H. Snell.--Is the ideal real? by G. A. Smith.--Some ethical tendencies in the professions, by R. D. Kohn.--On the art of living, by W. Boerner.--The relation of the ethical ideal to social reform, by J. L. Elliott.--Concerning tolerance, by R. F. Dewey.--Ethical culture in Germany after the war, by R. Penzig.--A confession of faith, by S. B. Weston.--"Hearing the witnesses," by J. Gutmann. (shrink)

G. Breit's original paper of 1929 postulates the Breit equation as a correction to an earlier defective equation due to Eddington and Gaunt, containing a form of interaction suggested by Heisenberg and Pauli. We observe that manifestly covariant electromagnetic Two-Body Dirac equations previously obtained by us in the framework of Relativistic Constraint Mechanics reproduce the spectral results of the Breit equation but through an interaction structure that contains that of Eddington and Gaunt. By repeating for our equation the analysis that (...) Breit used to demonstrate the superiority of his equation to that of Eddington and Gaunt, we show that the historically unfamiliar interaction structures of Two-Body Dirac equations (in Breit-like form) are just what is needed to correct the covariant Eddington Gaunt equation without resorting to Breit's version of retardation. (shrink)

…vel quod res omnes timide gelideque ministrat, dilator, † spe longus, iners avidusque futuri, diffcilis, querulus… I agree with Brink, and other editors referred to by him ad loe, that spe longus in Horace's description of the typical old man's character cannot be made to give sense. For earlier attempts at emendation, see Brink's note . Most of those who have tried to emend the passage concentrate on longus, and are reluctant to relinquish spe: this is largely due to (...) the parallel with Aristotle's account of the character of old men in Rhetoric 2. 13. 1389b 13ff., in which they are said to be, among other things it seems to me that this parallel should not be pressed too far. There is much in Aristotle that is not in Horace, and nothing to suggest close and detailed dependence. The parallel can only be relevant if spe longus can be turned into a reasonable Latin equivalent for Otherwise there is no good reason to suppose that spe is any less likely to be corrupt than longus. (shrink)

…vel quod res omnes timide gelideque ministrat,dilator, † spe longus, iners avidusque futuri,diffcilis, querulus…I agree with Brink, and other editors referred to by him ad loe, that spe longus in Horace's description of the typical old man's character cannot be made to give sense. For earlier attempts at emendation, see Brink's note. Most of those who have tried to emend the passage concentrate on longus, and are reluctant to relinquish spe: this is largely due to the parallel with Aristotle's (...) account of the character of old men in Rhetoric 2. 13. 1389b 13ff., in which they are said to be, among other things it seems to me that this parallel should not be pressed too far. There is much in Aristotle that is not in Horace, and nothing to suggest close and detailed dependence. The parallel can only be relevant if spe longus can be turned into a reasonable Latin equivalent for Otherwise there is no good reason to suppose that spe is any less likely to be corrupt than longus. (shrink)

Psychologists tend to examine their activities in experimentation with the same objective scientific attitude as they routinely assume in the experimental situation. A few psychologists have stepped outside this closed expistemic practice to undertake reflexive analysis of the psychologist in the laboratory. Three cases of such critical reflexive analysis are considered to better understand the strategies and consequences of confronting what Steve Woolgar has called ‘the horrors of reflexivity’. Reflexive work of William James, Horace Mann Bond, and Saul Rosenzweig (...) are examined: working in the early years of modern experimental psychology these scientists identified limitations in the dominant natural science model of experimentation. Attending to the scientist's own cognitions, social status, and unconscious processes respectively, James, Bond, and Rosenzweig criticized this natural science model and presented methodological and epistemic alternatives. The relative neglect of their constructive observations underscores the resistance to addressing psychology's reflexive dimensions. (shrink)

Horace Williams received a B.A. and an M.A. simultaneously at the University of North Carolina around 1883, taught in a preparatory school, received a Bachelor of Divinity degree at Yale in 1888, studied at Harvard for three years without working for a Ph.D., taught philosophy at the University of North Carolina from 1890 to 1940, and died in the latter year. His students included Senator Sam Ervin and U.S. Representative to the United Nations Frank Graham. Thomas Wolfe, who called (...) Williams the "Hegel of the cotton patch," modeled the character Virgil Weldon, in Look Homeward, Angel, after Williams. In 1968, a profile of Williams was published in the Reader’s Digest series "My Most Unforgettable Character.". (shrink)

Since the first selection of George Santayana's letters was published in 1955, shortly after his death, many more letters have been located. The Works of George Santayana, Volume V, brings together a total of more than 3,000 letters. The volume is divided chronologically into eight books of roughly comparable length. Book Two covers Santayana's first decade as a "freelance philosopher," following his resignation from Harvard University and move to Europe. Of particular interest is Santayana's continuing correspondence with the American philosopher (...) Charles Augustus Strong and with his sister Susana Sturgis de Sastre. Also included is correspondence with such notable figures as Bertrand Russell, Robert Seymour Bridges, Horace Kallen, and Logan Pearsall Smith. The correspondence covers Santayana's resignation from Harvard, his time in England during World War I, and comments on his philosophical work during this period. (shrink)

Book Three of George Santayana's letters covers a period of intense intellectual activity in Santayana's life, and the correspondence reflects the establishment of his mature philosophy. Santayana becomes more permanently established in Italy, but continues to travel in France, Spain, and England. The year 1927 marks the beginning of his long friendship with Daniel Cory, who became his literary secretary and eventually his literary executor. Also, with the death of Santayana's half-brother Robert, George Sturgis, Robert's son, becomes an important part (...) of Santayana's life and letters as his financial manager. Santayana continues to write to his sister Susana, as well as to numerous friends and fellow philosophers, including Bernard Berenson, Robert Seymour Bridges, Curt John Ducasse, John Erskine, Horace Meyer Kaller, Lewis Mumford, George Herbert Palmer, John Francis Stanley Russell, Herbert Wallace Schneider, Charles Augustus Strong, Paul Weiss, and Harry Austryn Wolfson. Other correspondents include Wendell T. Bush, Alys Gregory, Marianne Moore, John Middleton Murray, and Frederick J. E. Woodbridge. (shrink)

George Santayana published The Realm of Matter and The Genteel Tradition at Bay. He continued work on Book Three of Realms of Being, The Realm of Truth, and on his novel, The Last Puritan. Citing his commitment to his writing and his intention to retire from academia, he declined offers from Harvard University for the Norton Chair of Poetry and for a position as William James Professor of Philosophy, as well as offers for positions at the New School for Social (...) Research and Brown University. The deaths of his half sisters, Susan Sturgis de Sastre and Josephine Sturgis, in 1928 and 1930, respectively, were extremely distressing to him. Santayana and Charles Strong continued their epistolary debate over the nature and perception of reality and the problem of knowledge. The book also includes letters to Robert Bridges, Cyril Clemens, Morris R. Cohen, Curt John Ducasse, Sydney Hook, Horace Meyer Kallen, Walter Lippmann, Ralph Barton Perry, William Lyon Phelps, and Herbert W. Schneider. Santayana sent many letters with articles and reviews to journalists Wendell T. Bush, Henry Seidel Canby, Wilbur Cross, and John Middleton Murry. Discussion of his novel and continuing work on Realms of Being took place with Otto Kyllmann and John Hall Wheelock, his editors at Constable and Scribner's. Although Santayana now made the Hotel Bristol in Rome his permanent residence, he continued to travel in England, France, and Italy. (shrink)

The eight books of The Letters of George Santayana bring together over 3,000 letters, many of which have been discovered in the fifty years since Santayana's death. This sixth book covers four years of Santayana's life in Rome, his permanent residence since the late 1920s. During these years, Santayana, in his seventies, saw the publication of the remaining nine volumes of the Triton Edition of his work as well as the last two books of his Realms of Being: The Realm (...) of Truth and The Realm of Spirit. In 1938 the first book-length biography of Santayana was published, and in 1940 The Philosophy of George Santayana--a collection of critical essays that included Santayana's rejoinder, "Apologia pro Mente Sua"--was published as volume two of Northwestern University Press?s Library of Living Philosophers. In 1939, when war broke out in Europe and Swiss authorities denied him a long-term visa, Santayana decided to stay in Italy, where he was to remain for the rest of his life.The letters in this book are written to such correspondents as Van Meter Ames, Curt John Ducasse, Max Forrester Eastman, Max Fisch, Sidney Hook, Horace Meyer Kallen, Christopher Janus, Milton Munitz, William Lyon Phelps, and Ezra Pound, and include discussions of the work of Henri Bergson, T. S. Eliot, William Faulkner, and Ezra Pound, among others. (shrink)